Rosa Barrio Lab: Biomedicine research laboratory

ProteoCure: A European network to fine-tune the proteome.

Coux O*, Farràs R*; Core Group of ProteoCure

Biochimie 2024 Jun 18:S0300-9084(24)00140-8

doi: 10.1016/j.biochi.2024.06.004.

PMID: 38901793

Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination

Ayuso-García P, Sánchez-Rueda A, Velasco-Avilés S, Tamayo-Caro M, Ferrer-Pinós A, Huarte-Sebastian C, Alvarez V, Riobello C, Jiménez-Vega S, Buendia I, Cañas-Martin J, Fernández-Susavila H, Aparicio-Rey A, Esquinas-Román EM, Ponte CR, Guhl R, Laville N, Pérez-Andrés E, Lavín JL, González-Lopez M, Cámara NM, Aransay AM, Lozano JJ, Sutherland JD, Barrio R, Martinez-Chantar ML, Azkargorta M, Elortza F, Soriano-Navarro M, Matute C, Sánchez-Gómez MV, Bayón-Cordero L, Pérez-Samartín A, Bravo SB, Kurz T, Lama-Díaz T, Blanco MG, Haddad S, Record CJ, van Hasselt PM, Reilly MM, Varela-Rey M, Woodhoo A.*

Sci Adv. 2024 Apr 12;10(15):eadm7600

doi: 10.1126/sciadv.adm7600. Epub 2024 Apr 12

PMID: 38608019

SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

Lachiondo-Ortega S, Rejano-Gordillo CM, Simon J, Lopitz-Otsoa F, C Delgado T, Mazan-Mamczarz K, Goikoetxea-Usandizaga N, Zapata-Pavas LE, García-Del Río A, Guerra P, Peña-Sanfélix P, Hermán-Sánchez N, Al-Abdulla R, Fernandez-Rodríguez C, Azkargorta M, Velázquez-Cruz A, Guyon J, Martín C, Zalamea JD, Egia-Mendikute L, Sanz-Parra A, Serrano-Maciá M, González-Recio I, Gonzalez-Lopez M, Martínez-Cruz LA, Pontisso P, Aransay AM, Barrio R, Sutherland JD, Abrescia NGA, Elortza F, Lujambio A, Banales JM, Luque RM, Gahete MD, Palazón A, Avila MA, G Marin JJ, De S, Daubon T, Díaz-Quintana A, Díaz-Moreno I, Gorospe M, Rodríguez MS, Martínez-Chantar ML.*

Cell Rep. 2024 Mar 26;43(3):113924

doi: 10.1016/j.celrep.2024.113924. Epub 2024 Mar 18

PMID: 38507413

Biotin-based strategies to explore the world of ubiquitin and ubiquitin-like modifiers

Merino-Cacho L, Barroso-Gomila O, Hernández-Sánchez S, Ramirez J, Mayor U, Sutherland JD*, Barrio R*.

Chembiochem. 2023 Dec 11:e202300746

doi: 10.1002/cbic.202300746

PMID: 38081789

SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells

Seoane R, Lama-Díaz T, Romero AM, El Motiam A, Martínez-Férriz A, Vidal S, Bouzaher YH, Blanquer M, Tolosa RM, Castillo Mewa J, Rodríguez MS, García-Sastre A, Xirodimas D, Sutherland JD, Barrio R, Alepuz P, Blanco MG, Farràs R, Rivas C.*

Cell Mol Biol Lett. 2024 Jan 16;29(1):15

doi: 10.1186/s11658-024-00533-5

PMID: 38229033

BioE3 identifies specific substrates of ubiquitin E3 ligases.

Barroso-Gomila O, Merino-Cacho L, Muratore V, Perez C, Taibi V, Maspero E, Azkargorta M, Iloro I, Trulsson F, Vertegaal ACO, Mayor U, Elortza F, Polo S, Barrio R*, Sutherland JD*

Nat Commun. 2023 Nov 23;14(1):7656

doi: 10.1038/s41467-023-43326-8

PMID: 37996419

Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

Lenza MP, Egia-Mendikute L, Antoñana-Vildosola A, Soares CO, Coelho H, Corzana F, Bosch A, Manisha P, Quintana JI, Oyenarte I, Unione L, Moure MJ, Azkargorta M, Atxabal U, Sobczak K, Elortza F, Sutherland JD, Barrio R, Marcelo F, Jiménez-Barbero J*, Palazon A*, Ereño-Orbea J*.

Nat Commun. 2023 Jun 13;14(1):3496

doi: 10.1038/s41467-023-39119-8

PMID: 37311743