Rosa Barrio Lab researches ubiquitin proteins in development and rare diseases like Townes-Brocks Syndrome using innovative methods.

Polyamine-dependent metabolic shielding regulates alternative splicing.

Zabala-Letona A, Pujana-Vaquerizo M, Martinez-Laosa B, Ponce-Rodriguez M, Garcia-Longarte S, Mendizabal I, Gimeno A, Rogalska M, Tan J, Cabrera D, van Liempd S, Ximenez-Embun P, Espinosa S, Fagoaga-Eugui M, Peccati F, Zakrzewski M, Astobiza I, Arana-Castañares M, Cherkaoui S, Sendino M, Martín-Barros I, Ercilla A, Bozal-Basterra L, Carlevaris O, Arruabarrena-Aristorena A, Pérez-Andrés E, Santamaría-Zamorano T, Ferrer-Bonsoms JA, Carazo F, Cieśla M, Lobato C, Seoane J, Martín-Martín N, Barrio R, Sutherland JD, Aransay AM, Falcón-Pérez JM, Martínez-Pastor B, Rubio A, Blanco FJ, Hogarty MD, Morscher RJ, Berra E, Serwa RA, Jiménez-Barbero J, Jiménez-Osés G, Efeyan A, Finley L, Lizcano JM, Muñoz J, Valcarcel J, Carracedo A*.

Nature. 2026 Feb;650(8100):E4

doi: 10.1038/s41586-026-10140-3

PMID: 41565829

Rearrangement of the liver ubiquitome and NEDDylome in metabolic dysfunction-associated steatotic liver disease.

Delgado TC*, Lectez B, Serrano-Maciá M, Lopitz-Otsoa F, Uraga-Gracianteparaluceta L, Martínez-Arranz I, Arizmendi JM, Aloria K, Azkargorta M, Elortza F, Sutherland JD, Barrio R, Mayor U & Martínez-Chantar ML*

npj Gut Liver 2, 17 (2025)

doi: 10.1038/s44355-025-00032-0

SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation

El Motiam A, Bouzaher YH, Chen H, Seoane R, Vidal S, Blanquer M, Tolosa RM, Rodríguez-Lemus B, Herrera-Gavilán JA, Vidal A, Palmero I, Rodríguez MS, Sutherland JD, Barrio R, Xirodimas D, Collado M, Bremner R, Rivas C*.

Cell Death Dis. 2025 Jul 12;16(1):519

doi: 10.1038/s41419-025-07854-z.

PMID: 40651945

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

Bozal-Basterra L, Salazar MC, Ferreira Campos AM, Demicco M, Schmidt DR, Sobczak K, Ereño-Orbea J, Altea-Manzano P, Miranda Villanueva A, Martínez La Osa B, Garcia-Longarte S, Ponce-Rodriguez M, Mendizabal I, Carlevaris O, Astobiza I, Martin-Martin N, Zabala-Letona A, Talamillo A, Fernández-García J, Azkargorta M, Iloro I, Barrio R, Elortza F, Fendt SM, Vander Heiden MG, Barbero JJ, Sutherland JD, Carracedo A.*

bioRxiv [Preprint]. 2025 Jun 4:2025.06.02.657324

doi: 10.1101/2025.06.02.657324.

PMID: 40502001

Role of TRIM24 in the regulation of proteasome-autophagy crosstalk in bortezomib-resistant mantle cell lymphoma.

Corentin Bouvier, Maria Gonzalez-Santamarta, Nuria Profitos-Peleja, Marc Armengol, Wendy Xolalpa, Grégoire Quinet, Rune Matthiesen, James D. Sutherland, Rosa Barrio, Gael Roué* and Manuel S. Rodriguez*

Cell Death Discov. 2025 Mar 17;11(1):108

doi: 10.1038/s41420-025-02355-6

PMID: 40097385

Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome

Merino-Cacho L, Barroso-Gomila O, Pozo-Rodríguez M, Muratore V, Guinea-Pérez C, Serrano Á, Pérez C, Cano-López S, Urcullu A, Azkargorta M, Iloro I, Galdeano C, Juárez-Jiménez J, Mayor U, Elortza F, Barrio R*, Sutherland JD*.

Cell Communication and Signaling 23, 101 (2025)

doi: 10.1186/s12964-025-02091-5

PMID: 39972349

ProteoCure: A European network to fine-tune the proteome.

Coux O*, Farràs R*; Core Group of ProteoCure

Biochimie 2024 Jun 18:S0300-9084(24)00140-8

doi: 10.1016/j.biochi.2024.06.004.

PMID: 38901793

BioE3 identifies specific substrates of ubiquitin E3 ligases.

Barroso-Gomila O, Merino-Cacho L, Muratore V, Perez C, Taibi V, Maspero E, Azkargorta M, Iloro I, Trulsson F, Vertegaal ACO, Mayor U, Elortza F, Polo S, Barrio R*, Sutherland JD*

Nat Commun. 2023 Nov 23;14(1):7656

doi: 10.1038/s41467-023-43326-8

PMID: 37996419

U1A is a positive regulator of the expression of heterologous and cellular genes involved in cell proliferation and migration.

Rovira E, Moreno B, Razquin N, Hjerpe R, Gonzalez-Lopez M, Barrio R, Ruiz de Los Mozos I, Ule J, Pastor F, Blazquez L, Fortes P.

Mol Ther Nucleic Acids 2022 May 10;28:831-846

doi: 10.1016/j.omtn.2022.05.023. eCollection 2022 Jun 14

PMID: 35664701

Studying the ubiquitin code through biotin-based labelling methods

Barroso-Gomila O, Muratore V, Merino-Cacho L, Rodriguez JA, Barrio R*, Sutherland JD*

Semin Cell Dev Biol. 2022 Feb 15;S1084-9521(22)00047-7.

doi: 10.1016/j.semcdb.2022.02.009

PMID: 35181195

Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome.

Ramirez J, Lectez B, Osinalde N, Sivá M, Elu N, Aloria K, Procházková M, Perez C, Martínez-Hernández J, Barrio R, Grantz Šašková K, Arizmendi JM and Mayor U*

Human Molecular Genetics (2018) 27(11):1955-1971

doi: 10.1093/hmg/ddy103.

PMID: 29788202

Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster

Herboso L, Oliveira MM Talamillo A, Pérez C, González M, Martin D, Sutherland JD, Shingleton AW, Mirth C and Barrio R.*

Scientific Reports. (2015) 5: 12383

doi: 10.1038/srep12383

PMID: 26198204

Functional analysis of the SUMOylation pathway in Drosophila

Talamillo A, Sánchez J, Barrio R

Biochem Soc Trans. 2008 Oct;36(Pt 5):868-73.

doi: 10.1042/BST0360868

PMID: 18793153 Review

Regulation of R7 and R8 differentiation by the spalt genes

Domingos PM, Brown S, Barrio R, Ratnakumar K, Frankfort BJ, Mardon G, Steller H, Mollereau B

Dev Biol. 2004 Sep 1;273(1):121-33

doi: 10.1016/j.ydbio.2004.05.026

PMID: 15302602