Rosa Barrio Lab: Biomedicine research laboratory

Our research focuses on

studying biomedically relevant genes and processes, with a particular interest in understanding the role of members of the ubiquitin family (UbLs) in the regulation of development and their association with diseases, especially rare diseases.

We study Townes-Brocks Syndrome, a ciliopathy caused by truncations in SALL1 transcription factor, as well as other rare diseases related to the UbL family.We study Townes-Brocks Syndrome, a ciliopathy caused by truncations in SALL1 transcription factor, as well as other rare diseases related to the UbL family.

We are also actively involved in the development of innovative strategies to investigate the influence of UbL modifications on protein regulation and disease. These strategies include bioUbLs (to identify proteins modified by UbLs), SUMO-ID (to identify interactors of proteins when modified by UbLs), and BioE3 (to identify bona-fide targets of E3 ligases).

To accomplish this, we use in vivo biotinylation and mass spectrometry of proteins from human and mouse cultured cells, as well as using Drosophila melanogaster and mouse models, all leading to valuable insights for physiological and disease processes.

Non specialist info

Biomedicine research

Lab’s principal
lines of research

Sall & Rare Diseases

Spal-like (SALL) Family of Transcription Factors and rare diseases.

Ubiquitin-like proteins

Ubiquitin-like proteins in development and disease.

Tools to study ubiquitin

Tools to study ubiquitin-like modifications.

Ubiquitin related networks

We collaborate with networks to advance science in proteostasis

Selected publications

All publications

Ecdysone promotes growth of imaginal discs through the regulation of Thor in D. melanogaster

Herboso L, Oliveira MM Talamillo A, Pérez C, González M, Martin D, Sutherland JD, Shingleton AW, Mirth C and Barrio R.*

Scientific Reports. (2015) 5: 12383

doi: 10.1038/srep12383

PMID: 26198204

BioE3 identifies specific substrates of ubiquitin E3 ligases.

Barroso-Gomila O, Merino-Cacho L, Muratore V, Perez C, Taibi V, Maspero E, Azkargorta M, Iloro I, Trulsson F, Vertegaal ACO, Mayor U, Elortza F, Polo S, Barrio R*, Sutherland JD*

Nat Commun. 2023 Nov 23;14(1):7656

doi: 10.1038/s41467-023-43326-8

PMID: 37996419