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Enhancing Proteasome Activity in T Cells Alleviates Exhaustion and Improves Antitumor Immunity.

de Blas A, Andreatta M, Antoñana-Vildosola A, Velasco-Beltrán P, Egia-Mendikute L, Jimenez-Lasheras B, Bosch A, Barreira-Manrique A, Oyenarte I, Lee SY, Heuser-Loy C, Baldwin JG, Schelker RC, Martín-Santos A, Mastrogiovanni F, Azkargorta M, Elortza F, Sutherland JD, Torrano V, Aransay AM, Pérez-Gutiérrez L, Gros A, Carmona SJ, Gattinoni L, Ereño-Orbea J, Prieto-Fernández E, Palazon A. 

Cancer Res. 2026 Mar 26.

doi: 10.1158/0008-5472.CAN-25-1246.

PMID: 41886620

Polyamine-dependent metabolic shielding regulates alternative splicing.

Zabala-Letona A, Pujana-Vaquerizo M, Martinez-Laosa B, Ponce-Rodriguez M, Garcia-Longarte S, Mendizabal I, Gimeno A, Rogalska M, Tan J, Cabrera D, van Liempd S, Ximenez-Embun P, Espinosa S, Fagoaga-Eugui M, Peccati F, Zakrzewski M, Astobiza I, Arana-Castañares M, Cherkaoui S, Sendino M, Martín-Barros I, Ercilla A, Bozal-Basterra L, Carlevaris O, Arruabarrena-Aristorena A, Pérez-Andrés E, Santamaría-Zamorano T, Ferrer-Bonsoms JA, Carazo F, Cieśla M, Lobato C, Seoane J, Martín-Martín N, Barrio R, Sutherland JD, Aransay AM, Falcón-Pérez JM, Martínez-Pastor B, Rubio A, Blanco FJ, Hogarty MD, Morscher RJ, Berra E, Serwa RA, Jiménez-Barbero J, Jiménez-Osés G, Efeyan A, Finley L, Lizcano JM, Muñoz J, Valcarcel J, Carracedo A*.

Nature. 2026 Feb;650(8100):E4

doi: 10.1038/s41586-026-10140-3

PMID: 41565829

Loss of UFMylation supports prostate cancer metastasis and rewires cell metabolism towards hexosamine biosynthesis

Bozal-Basterra L, Salazar MC, Ferreira Campos AM, Demicco M, Schmidt DR, Sobczak K, Ereño-Orbea J, Altea-Manzano P, Miranda Villanueva A, Martínez La Osa B, Garcia-Longarte S, Ponce-Rodriguez M, Mendizabal I, Carlevaris O, Astobiza I, Martin-Martin N, Zabala-Letona A, Talamillo A, Fernández-García J, Azkargorta M, Iloro I, Barrio R, Elortza F, Fendt SM, Vander Heiden MG, Barbero JJ, Sutherland JD, Carracedo A.*

bioRxiv [Preprint]. 2025 Jun 4:2025.06.02.657324

doi: 10.1101/2025.06.02.657324.

PMID: 40502001

Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway

Gil-Pitarch C, Serrano-Maciá M, Simon J, Mosca L, Conter C, Rejano-Gordillo CM, Zapata-Pavas LE, Peña-Sanfélix P, Azkargorta M, Rodríguez-Agudo R, Lachiondo-Ortega S, Mercado-Gómez M, Delgado TC, Porcelli M, Aurrekoetxea I, Sutherland JD, Barrio R, Xirodimas D, Aspichueta P, Elortza F, Martínez-Cruz LA, Nogueiras R, Iruzubieta P, Crespo J, Masson S, McCain MV, Reeves HL, Andrade RJ, Lucena MI, Mayor U, Goikoetxea-Usandizaga N, González-Recio I, Martínez-Chantar ML.*

Cell Rep Med. 2024 Jul 16;5(7):101653. doi: 10.1016/j.xcrm.2024.101653

PMID: 39019009